Related Experiment Video
Updated: May 30, 2026

Generating and Co-culturing Murine Primary Microglia and Cortical Neurons
Published on: July 26, 2024
Astrocytes and microglia: responses to neuropathological conditions
Sarika Singh1, Supriya Swarnkar, Poonam Goswami
1Toxicology Division, Central Drug Research Institute-CSIR-CDRI, Lucknow, India. ssj3010@yahoo.co.in
Abstract:
Activated astrocytes and microglia, hallmark of neurodegenerative diseases release different factors like array of pro and anti-inflammatory cytokines, free radicals, anti-oxidants, and neurotrophic factors during neurodegeneration which further contribute to neuronal death as well as in survival mechanisms. Astrocytes act as double-edged sword exerting both detrimental and neuroprotective effects while microglial cells are attributed more in neurodegenerative mechanisms. The dual and insufficient knowledge about the precise role of glia in neurodegeneration showed the need for further investigations and thorough review of the function of glia in neurodegeneration. In this review, we consolidate and categorize the glia-released factors which contribute in degenerative and protective mechanisms during neuropathological conditions.
Related Concept Videos
Glial Cells
Nervous Tissue: Glial Cells
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial cells that interact...
Neurogenesis and Regeneration of Nervous Tissue
Encephalitis ll: Pathophysiology
