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Related Experiment Videos

Plasma lecithin:cholesterol acyltransferase activity in hypophysectomized rats.

V Manninen, M Mälkönen, J P Blomhoff

    Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum
    |January 1, 1978
    PubMed
    Summary

    Hypophysectomy in rats significantly reduces lecithin:cholesterol acyltransferase (LCAT) activity and alters lipoprotein profiles, impacting cholesterol metabolism. These changes suggest a complex hormonal regulation of LCAT and lipid transport.

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    Area of Science:

    • Endocrinology
    • Lipid Metabolism
    • Biochemistry

    Background:

    • Hypophysectomy in rats alters lipoprotein profiles, decreasing VLDL and HDL while increasing LDL.
    • The role of lecithin:cholesterol acyltransferase (LCAT) in these lipid changes requires further investigation.

    Purpose of the Study:

    • To investigate the impact of hypophysectomy on plasma LCAT activity in rats.
    • To explore the relationship between LCAT activity and altered lipoprotein metabolism post-hypophysectomy.

    Main Methods:

    • Rats underwent hypophysectomy.
    • Plasma LCAT activity was measured using Stokke-Norum and Glomset-Wright methods.
    • Lipoprotein levels, cholesterol, triglycerides, blood glucose, FFA, and red blood cell parameters were analyzed.

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    Main Results:

    • Hypophysectomy significantly decreased plasma LCAT activity.
    • Plasma total and free cholesterol showed a slight increase; cholesteryl esters and triglycerides remained unchanged.
    • Red blood cell osmotic resistance increased, with target cells observed; hemoglobin and hematocrit decreased.

    Conclusions:

    • Reduced LCAT activity post-hypophysectomy may be linked to decreased liver secretion of LCAT and VLDL.
    • The complex interplay between lipoproteins and LCAT prevents definitive conclusions on HDL reduction.
    • Hormonal control mechanisms governing LCAT activity and lipoprotein metabolism require further elucidation.