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Updated: May 30, 2026

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Antimicrobial Peptides Produced by Selective Pressure Incorporation of Non-canonical Amino Acids

Published on: May 4, 2018

Lacticin 3147--biosynthesis, molecular analysis, immunity, bioengineering and applications.

Srinivas Suda¹, Paul D Cotter, Colin Hill

¹Department of Microbiology, University College Cork, Cork, Ireland.

Current Protein & Peptide Science

|August 11, 2011

Summary

Lantibiotics, like lacticin 3147, are potent antimicrobial peptides offering a promising solution to rising multidrug resistance. Research highlights their broad-spectrum activity against pathogens in food, veterinary, and potentially human medicine.

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Using the Overlay Assay to Qualitatively Measure Bacterial Production of and Sensitivity to Pneumococcal Bacteriocins

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Published on: September 30, 2014

Area of Science:

Microbiology
Biochemistry
Molecular Biology

Background:

The rise of multidrug-resistant pathogens necessitates novel antimicrobial agents.
Lantibiotics, a class of bacteriocin, exhibit broad-spectrum antimicrobial activity.
Lacticin 3147, a two-peptide lantibiotic, has shown significant potential against various pathogens.

Purpose of the Study:

To review the accumulated knowledge on lacticin 3147 since its discovery.
To explore the potential of lacticin 3147 as a therapeutic antimicrobial agent.
To highlight advancements in understanding lacticin 3147 biosynthesis, immunity, and bioengineering.

Main Methods:

Literature review of research on lacticin 3147.
Analysis of studies on lacticin 3147 biosynthesis and immunity.
Evaluation of research on structure-function relationships and bioengineering of lacticin 3147.

Main Results:

Lacticin 3147 demonstrates potent activity against a wide range of pathogens at low concentrations.
Extensive research has elucidated mechanisms of lacticin 3147 biosynthesis and immunity.
Molecular bioengineering studies reveal potential for enhanced antimicrobial properties.

Conclusions:

Lantibiotics, particularly lacticin 3147, represent a viable strategy against multidrug resistance.
Lacticin 3147 holds promise for applications in food preservation, veterinary medicine, and potentially human therapeutics.
Continued research into lacticin 3147 and similar lantibiotics is crucial for combating antimicrobial resistance.