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Updated: May 30, 2026
07:37
Roux-en-Y Gastric Bypass Operation in Rats
Published on: June 11, 2012
Alterations of sucrose preference after Roux-en-Y gastric bypass
M Bueter1, A D Miras, H Chichger
1Department of Investigative Medicine, Imperial Weight Centre, Imperial College London, London, UK.
Physiology & Behavior
|August 11, 2011
Summary
Roux-en-Y gastric bypass surgery alters sweet taste perception and intake. While rats show reduced sucrose preference, human taste sensitivity changes don't alter hedonic ratings, suggesting complex post-surgery food preference factors.
Area of Science:
- Bariatric Surgery
- Gastroenterology
- Neuroscience
Background:
- Roux-en-Y gastric bypass (RYGB) is associated with altered sweet food perception and consumption.
- Understanding these changes is crucial for managing post-surgical dietary habits and patient outcomes.
Purpose of the Study:
- To investigate alterations in sweet food intake in rats and sucrose detection thresholds in humans following RYGB.
- To explore the relationship between taste perception changes and hedonic responses to sweetness post-surgery.
Main Methods:
- Wistar rats underwent RYGB or sham operations, with subsequent two-bottle intake tests for sucrose and other taste compounds.
- Intestinal T1R2/T1R3 expression and plasma levels of GLP-1 and PYY were measured in rats.
- Obese patients and normal-weight controls had pre- and post-operative sucrose taste detection thresholds and hedonic perception assessed.
Main Results:
- RYGB reduced sucrose intake in rats, an effect attenuated by preoperative sucrose exposure.
- Intestinal T1R2/T1R3 expression decreased, while GLP-1 and PYY levels increased post-RYGB in rats.
- Bypass patients exhibited increased taste sensitivity to low sucrose concentrations, yet hedonic ratings remained similar to controls.
Conclusions:
- RYGB reduces sucrose intake in sucrose-naïve rats, with preoperative experience mitigating this effect.
- Altered taste sensitivity post-RYGB in humans does not necessarily predict changes in hedonic taste ratings.
- Factors beyond basic taste perception, such as learned associations, likely influence food preferences after gastric bypass.
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