Related Experiment Video
Updated: May 30, 2026
14:39
Bronchial Thermoplasty: A Novel Therapeutic Approach to Severe Asthma
Published on: November 4, 2010
Mometasone furoate/formoterol reduces asthma deteriorations and improves lung function
1Allergy and Asthma Medical Group and Research Center, 9610 Granite Ridge Drive, Suite B, San Diego, CA 92123, USA. EOMELTZER@aol.com
The European Respiratory Journal
|August 11, 2011
Summary
This study shows mometasone furoate/formoterol (MF/F) combination therapy significantly reduces asthma deteriorations and improves lung function compared to individual components. Both mometasone furoate and formoterol contribute to the enhanced efficacy of the MF/F inhaler.
Area of Science:
- Pulmonology
- Pharmacology
- Clinical Trials
Background:
- Asthma management often requires combination therapy for optimal control.
- Inhaled corticosteroids (ICS) and long-acting beta-agonists (LABA) are key components of asthma treatment.
- Evaluating the contribution of each component in a fixed-dose combination is crucial for understanding therapeutic benefits.
Purpose of the Study:
- To assess the efficacy of mometasone furoate (MF)/formoterol (F) versus its monocomponents in managing asthma.
- To determine the individual contributions of MF and F within the combination therapy.
- To evaluate the impact on asthma exacerbations and lung function.
Main Methods:
- A 26-week, multicenter, double-blind, placebo-controlled trial.
- 746 participants with not well-controlled asthma were randomized to MF/F, MF, F, or placebo.
- Co-primary endpoints included time to first asthma deterioration and change in FEV(1) AUC(0-12h).
Main Results:
- MF/F significantly reduced asthma deterioration incidence and delayed time to first deterioration compared to F alone (p<0.001).
- MF/F demonstrated a significant improvement in FEV(1) AUC(0-12h) compared to MF alone (4.00 vs 2.53 L·h, p=0.001).
- The combination therapy also showed improved quality of life and greater clinical efficacy than monotherapy or placebo.
Conclusions:
- Mometasone furoate/formoterol (MF/F) 100/10 μg BID offers superior clinical efficacy in asthma management compared to its individual components.
- Both mometasone furoate and formoterol contribute significantly to the therapeutic benefits of the MF/F combination.
- MF/F is an effective treatment option for patients with not well-controlled asthma.
Related Concept Videos
01:19Antiasthma Drugs: Leukotriene Modifiers
Leukotriene modifiers, or cysteinyl leukotriene receptor antagonists, are medications used to manage chronic asthma. These agents target specific inflammatory mediators produced during arachidonic acid metabolism, an essential process in generating inflammation in the body.
Leukotriene modifiers work through two distinct mechanisms:
Leukotriene modifiers work through two distinct mechanisms:
01:25Antiasthma Drugs: β2-Adrenoceptor Agonists
Bronchodilators are critical in managing asthma, a chronic respiratory condition characterized by airway constriction due to inflammation and hyper-reactivity. Specifically, bronchodilators ease this constriction by relaxing the bronchial muscles, facilitating easier breathing.
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
One class of bronchodilators includes β2-adrenoceptor agonists. These agents target the β2-adrenoceptors located on bronchial smooth muscle cells. By stimulating these receptors, β2-agonists induce relaxation in these...
01:23Inhaled Medications
Inhaled medications are crucial for managing chronic obstructive pulmonary disease (COPD) and asthma. They are essential for effective treatment and control, ensuring optimal respiratory health and well-being. Inhaled medication delivers drugs directly to the lungs, providing a rapid onset of action and reducing systemic side effects compared to oral or injectable medications. Three primary types of inhalation devices are used to administer these medications: nebulizers, metered-dose inhalers...
01:25Antiasthma Drugs: Mast Cell Stabilizers and Anti-IgE Drugs
Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
Mast cell stabilizers, such as cromolyn (also known as sodium cromoglycate) and nedocromil (Tilade), are effective drugs in asthma management. These stabilizers hinder histamine release by skillfully obstructing the activation of mast cells and other cellular entities. Notably, they navigate this task without...
01:17Drugs Used in Lower Respiratory Disorders: Overview
Lower respiratory tract disorders present challenges that often require skilled and nuanced approaches for effective management. Common ailments, such as asthma and chronic obstructive pulmonary disease (COPD), have prompted the development of intricate treatment strategies involving bronchodilators and anti-inflammatory drugs, each tailored to ease breathing and revitalize the lungs.
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
Bronchodilators, the first step of respiration enhancement, come in various forms, each with its own mechanism...
01:25Antiasthma Drugs: Inhaled Corticosteroids and Glucocorticoids
Inhaled corticosteroids (ICS) are anti-inflammatory drugs used primarily in treating persistent asthma and providing long-term maintenance. They target the bronchial mucosa, the lining of the airways, to control inflammation, a critical factor in asthma progression and exacerbation.
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...
ICS work through a multifaceted mechanism of action. They suppress the inflammatory response caused by the proliferation of TH cells. They also reduce the transcription of the IL-2 gene, which is involved in the...