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Related Experiment Video

Updated: May 30, 2026

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification
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Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

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Dynamic causal models and physiological inference: a validation study using isoflurane anaesthesia in rodents.

Rosalyn J Moran1, Fabienne Jung, Tetsuya Kumagai

  • 1Wellcome Trust Centre for Neuroimaging, Institute of Neurology, University College London, London, United Kingdom. r.moran@fil.ion.ucl.ac.uk

Plos One
|August 11, 2011
PubMed
Summary

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Dynamic causal modeling (DCM) successfully inferred drug-induced changes in excitatory and inhibitory synaptic transmission from rodent brain activity. This validates DCM

Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Systems Neuroscience

Background:

  • Generative models offer novel ways to study latent brain states.
  • Dynamic causal modeling (DCM) infers synaptic mechanisms from brain responses.
  • DCM for electrophysiological data estimates synaptic transmission strength and neurotransmitter roles.

Purpose of the Study:

  • To validate DCM's capacity to infer excitatory and inhibitory synaptic transmission changes.
  • To assess DCM's ability to detect anaesthetic-induced alterations in synaptic processing.
  • To test inference on glutamatergic (AMPA) and GABAergic (GABA(A)) receptor-mediated transmission.

Main Methods:

  • Recorded local field potentials (LFPs) from rodent auditory cortex (A1) and posterior auditory field (PAF).

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Last Updated: May 30, 2026

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification
03:02

Application of Dixon's Up-and-Down Design to Estimate the Minimum Alveolar Concentration of Sevoflurane in Rats with Refined Movement Classification

Published on: July 25, 2025

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention
08:49

Assessing Changes in Volatile General Anesthetic Sensitivity of Mice after Local or Systemic Pharmacological Intervention

Published on: October 16, 2013

  • Applied different doses of isoflurane anaesthetic to modulate synaptic processing.
  • Optimized three DCMs using cross- and auto-spectra, neural mass models, and network architectures.

    • Main Results:

    • A model with forward (A1 to PAF) and backward (PAF to A1) connections was most plausible, reflecting sensory hierarchy.
    • Parameter estimates showed glutamatergic excitatory postsynaptic potentials (EPSPs) decreased linearly with anaesthesia.
    • Inhibitory postsynaptic potentials (IPSPs) increased non-linearly (saturating) with increasing anaesthesia.

    Conclusions:

    • DCM accurately infers drug-induced changes in excitatory and inhibitory synaptic transmission in vivo.
    • Results align with prior in vitro neurophysiological findings, confirming DCM's validity.
    • DCM provides a powerful tool for studying synaptic mechanisms using macroscopic neurophysiological data.