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Induction of Maternal Immune Activation in Mice at Mid-gestation Stage with Viral Mimic Poly(I:C)
Published on: March 25, 2016
Unification of the findings in schizophrenia by reference to the effects of gestational zinc deficiency
1Charing Cross Hospital, Haematology Department, Fulham, London, UK.
The hypothesis presented here suggests that schizophrenia is caused by the action of gestational zinc deficiency on genetically susceptible foetuses. The psychosis seen is suggested to be due to a combination of dietary or otherwise induced zinc deficiency and lack of zinc releasing capacity in the hippocampus. A non genetic but transmissable immune defect is suggested to be relevant to psychosis and to the nonmendelian pattern of inheritance of the disorder.
The hypothesis presented here suggests that schizophrenia is caused by the action of gestational zinc deficiency on genetically susceptible foetuses. The psychosis seen is suggested to be due to a combination of dietary or otherwise induced zinc deficiency and lack of zinc releasing capacity in the hippocampus. A non genetic but transmissable immune defect is suggested to be relevant to psychosis and to the nonmendelian pattern of inheritance of the disorder.
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