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Diabetic nephropathy--are there differences between type I and type II?

E Ritz1, C Hasslacher, W Tschöpe

  • 1Department of Internal Medicine, Ruperto Karola University, Heidelberg, FRG.

Mineral and Electrolyte Metabolism
|January 1, 1990
PubMed
Summary
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Renal risk in type II diabetes is not as low as previously assumed. Both type I and type II diabetes patients face comparable risks for kidney complications like proteinuria and renal failure.

Area of Science:

  • Nephrology
  • Endocrinology
  • Diabetology

Background:

  • Type II diabetes is often considered to have a lower renal risk compared to type I diabetes.
  • Historically, only 5% of type II diabetes patients develop renal failure versus 40% of type I diabetes patients.

Purpose of the Study:

  • To compare the cumulative renal risk between type I and type II diabetes.
  • To investigate the risk of proteinuria and renal failure in type II diabetes patients.

Main Methods:

  • Observation of patients in the diabetes outpatient department at the University of Heidelberg.
  • Analysis of cumulative risk for proteinuria and renal failure.

Main Results:

  • The cumulative risk of proteinuria for nonproteinuric type II diabetics is comparable to type I diabetics.

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  • The cumulative risk of renal failure for proteinuric type II diabetics is comparable to type I diabetics.
  • No clear evidence of hyperfiltration in early type II diabetes was observed.

    • Conclusions:

    • The renal risk in type II diabetes may be underestimated.
    • Type II diabetes presents a valuable model for studying the hyperfiltration theory in kidney disease.
    • Further research is needed to understand the mechanisms driving renal complications in type II diabetes.