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Rituximab in steroid refractory autoimmune hemolytic anemia
Nitin Gupta1, Sanjeev Sharma, Tulika Seth
1Department of Hematology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Abstract:
Autoimmune hemolytic anemia is rare in children and infants and steroids are the corner stone of therapy. Management of the patients with steroid refractory/dependent disease is difficult .Rituximab is being used in the treatment of a variety of autoimmune diseases including Autoimmune hemolytic anemia (AIHA),especially in adults but there is scarce data regarding the use of this agent in pediatric AIHA patients.The authors report two cases of steroid refractory AIHA, who responded to rituximab with review the literature of its use in pediatrics.
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