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Core/shell Printing Scaffolds For Tissue Engineering Of Tubular Structures
Published on: September 27, 2019
Extrusion based rapid prototyping technique: an advanced platform for tissue engineering scaffold fabrication.
M Enamul Hoque1, Y Leng Chuan, Ian Pashby
1Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham Malaysia Campus, Jalan Broga, Selangor Darul Ehsan, Malaysia. Enamul.Hoque@nottingham.edu.my
Biopolymers
|August 11, 2011
Summary
Rapid prototyping (RP) offers advanced 3D scaffold fabrication for tissue engineering (TE), overcoming limitations of conventional methods. Extrusion-based RP allows precise control over scaffold architecture for patient-specific applications.
Area of Science:
- Biomaterials Science
- Tissue Engineering
- Additive Manufacturing
Background:
- Conventional scaffold fabrication methods lack control over pore morphology, architecture, and reproducibility.
- Tissue engineering requires scaffolds that mimic native tissue biomechanical properties.
- Rapid prototyping (RP) offers a solution for creating complex, patient-specific 3D scaffolds.
Purpose of the Study:
- To provide an intensive description of extrusion-based scaffold fabrication techniques.
- To review the potential utility of these techniques for tissue engineering applications.
- To assess the current state and future prospects of extrusion-based RP for scaffold fabrication.
Main Methods:
- Focuses on extrusion-based rapid prototyping (RP) techniques.
- Describes the layer-by-layer additive manufacturing process.
- Highlights control over pore architecture in the x- and y-planes.
Main Results:
- RP enables the creation of complex 3D scaffold architectures with tailored properties.
- Extrusion-based RP allows customization to mimic native tissue biomechanics.
- Control over pore height in the z-direction is limited by nozzle diameter.
Conclusions:
- Extrusion-based RP is a promising technology for advanced tissue engineering scaffolds.
- Patient-specific scaffold design and fabrication are achievable with RP.
- Further development is needed to overcome limitations in z-direction pore control.
