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Related Concept Videos

The Effect of Aging on Tissues01:19

The Effect of Aging on Tissues

Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
Aging01:26

Aging

Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption01:22

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Absorption

As individuals age, their body's physiology evolves, affecting drug pharmacokinetics. The most apparent changes occur in the gastrointestinal tract, where an increase in gastric pH, a delay in gastric emptying, and a reduction in gastrointestinal motility are observed. Remarkably, these changes do not substantially modify the absorption of orally administered drugs, particularly those absorbed via passive diffusion.Transdermal drug delivery emerges as a highly viable method for older adults due...
Renewal of Skin Epidermal Stem Cells01:12

Renewal of Skin Epidermal Stem Cells

The skin is divided into epidermis, dermis, and hypodermis, the skin's outermost, middle, and inner layers. The human epidermal layer regularly undergoes renewal, where old, dead cells are replaced by new cells. Epidermal stem cells or EpiSCs divide and differentiate to restore the lost cells. For the renewal process, some EpiSCs continuously self-renew. In contrast, few others differentiate into transit-amplifying cells, which later form prickle or spinous cells, followed by granular cells,...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Bone Disorders01:29

Bone Disorders

Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
Bone deposition is also affected by the levels of sex hormones like estrogen and testosterone that promote osteoblast activity and bone matrix synthesis. When the level of these hormones decreases due to aging, it causes a reduction in bone deposition. As a result, bone resorption by osteoclasts...

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Related Experiment Video

Updated: May 30, 2026

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
03:47

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid

Published on: September 27, 2024

Skin aging.

Ines Sjerobabski-Masnec1, Mirna Situm

  • 1University Department of Dermatovenereology, Sestre milosrdnice University Hospital, Zagreb, Croatia. ines@kbsm.hr

Acta Clinica Croatica
|August 12, 2011
PubMed
Summary

Skin aging results from intrinsic (time-dependent) and extrinsic (environmental) factors. Photoaging, caused by UV exposure, significantly damages skin, leading to wrinkles and neoplasms.

Area of Science:

  • Dermatology
  • Aesthetic Medicine
  • Gerontology

Background:

  • Skin aging is a complex degenerative process affecting the skin and its support structures.
  • Intrinsic aging (chronological) is genetically determined and time-dependent, leading to skin atrophy and reduced elasticity.
  • Extrinsic aging results from environmental factors, with ultraviolet (UV) radiation being the most significant contributor, causing photoaging.

Purpose of the Study:

  • To differentiate between intrinsic and extrinsic skin aging processes.
  • To detail the clinical manifestations and molecular responses associated with photoaging.
  • To highlight the impact of UV exposure on skin structure and health.

Main Methods:

  • Review of existing literature on skin aging mechanisms.

Related Experiment Videos

Last Updated: May 30, 2026

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid
03:47

Enhancement of Facial Rejuvenation Through a Combination of 1565 nm Non-Ablative Fractional Laser with 30% Supramolecular Salicylic Acid

Published on: September 27, 2024

  • Clinical observation and characterization of age-related skin changes.
  • Analysis of molecular responses to UV irradiation.

    • Main Results:

    • Intrinsic aging leads to fine wrinkles, thinning skin, fat loss, and reduced metabolic activity.
    • Extrinsic aging, particularly photoaging, causes coarse wrinkling, dryness, laxity, and pigmentary changes in sun-exposed areas.
    • UV exposure triggers molecular responses damaging connective tissue and increasing neoplasm development.

    Conclusions:

    • Skin aging is a dual process influenced by genetics and environment.
    • Photoaging is a major contributor to visible skin aging and necessitates sun protection.
    • Understanding these processes is crucial for developing effective anti-aging strategies.