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Chitosan coated furosemide liposomes for improved bioavailability
Imran Vural1, Can Sarisozen, Senem Sevtap Olmez
1Pharmaceutical Technology Department, Faculty of Pharmacy, Hacettepe University, 06100 Ankara, Turkey.
Journal of Biomedical Nanotechnology
|August 12, 2011
Summary
Chitosan-coated liposomes significantly enhanced furosemide permeability and reduced cytotoxicity, suggesting potential for improving oral bioavailability of poorly soluble drugs.
Area of Science:
- Pharmaceutics
- Drug Delivery
- Biomaterials
Background:
- Furosemide is a diuretic with poor oral bioavailability.
- Liposomes are lipid-based nanoparticles used for drug delivery.
- Chitosan is a biocompatible polysaccharide with mucoadhesive properties.
Purpose of the Study:
- To prepare and characterize furosemide-loaded chitosan-coated liposomes.
- To evaluate the effect of chitosan coating on liposome properties.
- To assess the in vitro performance of the formulations for drug delivery.
Main Methods:
- Liposomes were prepared using the evaporation-sonication method.
- Chitosan coating was applied to the liposomes.
- Characterization included particle size, zeta potential, encapsulation efficiency, and cell viability (MTT assay).
- Permeability studies were conducted on Caco-2 cell monolayers.
Main Results:
- Chitosan coating increased encapsulation efficiency, zeta potential, and particle size.
- Coated liposomes showed an eight-fold increase in furosemide permeability compared to uncoated ones.
- Cytotoxicity of furosemide-loaded liposomes decreased upon chitosan coating.
- Improved drug loading and enhanced permeability were observed.
Conclusions:
- Furosemide-loaded chitosan-coated liposomes demonstrate improved pharmaceutical characteristics.
- Chitosan coating enhances drug permeability and reduces cytotoxicity.
- These formulations show promise as effective carriers for improving oral bioavailability of poorly soluble drugs like furosemide.
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