ERG oncoprotein overexpression in prostate cancer. Multiplex IHC adds to diagnostic prowess and efficiency of laboratory

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Mark Cross1

  • 1Biocare Medical, Concord, CA, USA. mcross@biocare.netbiocare.net

MLO: Medical Laboratory Observer
|August 12, 2011
PubMed
Abstract

No abstract available in PubMed .

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Immunocytochemistry (ICC) and immunohistochemistry (IHC) are techniques that use antibodies to check for specific proteins or antigens in a sample. The technique was first published by Albert Coons in 1941 to detect the presence of pneumococcal antigen in tissue sections from mice infected with Pneumococcus. Immunocytochemistry helps localization of proteins or antigens in individual cells like blood cells, stem cells, etc., while immunohistochemistry does the same for tissue samples.
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