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Related Concept Videos

Bioavailability Enhancement: Drug Permeability Enhancement01:27

Bioavailability Enhancement: Drug Permeability Enhancement

After oral administration, poor permeability often limits the rate at which drugs are absorbed through the intestinal epithelium. Enhancing drug permeability is crucial for effective therapy, and several strategies have been developed to overcome this challenge.One effective strategy involves the use of lipid-based formulations. These formulations enhance dissolution and solubility, targeting physiological mechanisms to increase drug absorption. This includes stimulating bile salt secretion,...
Bioavailability Enhancement: Drug Solubility Enhancement01:16

Bioavailability Enhancement: Drug Solubility Enhancement

Bioavailability is a critical factor in determining a drug's effectiveness. It refers to the proportion of a drug that enters the circulation when introduced into the body and is, as a result, able to have an active effect. Enhancing bioavailability is essential for drugs with poor solubility, as it can significantly impact their therapeutic efficacy. Various methods are employed to increase the solubility of drugs, thereby enhancing their bioavailability.Micronization and nanonization are...
Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems01:22

Bioavailability Enhancement: Determination and Conceptual Approaches in Overcoming Bioavailability Problems

Bioavailability is a critical pharmacological concept that measures the extent and rate at which an active drug ingredient or therapeutic moiety enters the systemic circulation, remaining unchanged. It's a pivotal factor in determining a drug's efficacy and safety.The Biopharmaceutics Classification System (BCS) plays an essential role in drug development by categorizing drugs into four classes based on their solubility and permeability. This classification aids in understanding drug absorption...
Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are employed to...
Oral Drug Delivery Systems: Introduction01:23

Oral Drug Delivery Systems: Introduction

Oral drug delivery is the most common route of administration due to its convenience, cost-effectiveness, and high patient compliance. It enables precise formulation to ensure proper drug dosage and bioavailability. The development of oral dosage forms considers drug properties such as solubility, stability, and absorption to optimize therapeutic efficacy.Tablets, capsules, liquids, and chewable formulations enhance drug stability, mask undesirable tastes, and improve patient experience.

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Self-Nanoemulsification of Healthy Oils to Enhance the Solubility of Lipophilic Drugs
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Published on: July 27, 2022

Solid lipid nanoparticles: an oral bioavailability enhancer vehicle.

Harshad Harde1, Manasmita Das, Sanyog Jain

  • 1National Institute of Pharmaceutical Education and Research, Centre for Pharmaceutical Nanotechnology, Department of Pharmaceutics, SAS Nagar, Punjab, India.

Expert Opinion on Drug Delivery
|August 12, 2011
PubMed
Summary

Solid lipid nanoparticles (SLNs) enhance oral drug bioavailability by protecting drugs from degradation and improving stability. This technology offers a scalable, solvent-free method to boost drug efficacy for various drug classes.

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Published on: July 27, 2022

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Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications
08:19

Solid Lipid Nanoparticles (SLNs) for Intracellular Targeting Applications

Published on: November 17, 2015

Area of Science:

  • Nanotechnology in drug delivery
  • Pharmaceutical sciences
  • Biopharmaceutics

Background:

  • Poor oral bioavailability (BA) and metabolic instability limit oral drug efficacy.
  • Solid lipid nanoparticles (SLNs) are investigated as vehicles to enhance oral BA.
  • SLNs are suitable for Class II, III, and IV drug molecules.

Purpose of the Study:

  • To review advancements in SLN technology for oral drug delivery.
  • To critically examine the impact of SLN constituents on absorption and applications.
  • To explore the relationship between SLN properties (particle size, stability, self-emulsification) and absorption.

Main Methods:

  • Literature review of recent advancements in SLN technology.
  • Critical examination of factors influencing SLN absorption in oral drug delivery.
  • Analysis of the relationship between lipid properties and SLN performance.

Main Results:

  • SLNs protect drugs from premature degradation in the gastrointestinal tract (GIT).
  • SLNs provide sustained/controlled drug release, improving stability.
  • Direct peroral administration of SLNs increased drug BA by 2- to 25-fold.

Conclusions:

  • SLNs improve drug stability and bioavailability in the GIT.
  • SLNs offer a scalable, solvent-free approach for oral drug delivery.
  • SLNs are promising BA enhancers for various drug classes.