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Updated: May 30, 2026

Isolation and Characterization of Dendritic Cells and Macrophages from the Mouse Intestine
Published on: May 21, 2012
Regulation of Th17 cell differentiation by intestinal commensal bacteria
K Atarashi1, T Tanoue, Y Umesaki
1Department of Immunology, Graduate School of Medicine, University of Tokyo, Tokyo 113-0033, Japan.
Abstract:
Interleukin (IL)-17-producing CD4 T cells ('Th17 cells') are most abundant at the intestinal mucosa, and play a critical role in the maintenance of mucosal barrier function. Recent studies indicate that accumulation of intestinal Th17 cells depends on stimulation by intestinal commensal bacteria - particularly by segmented filamentous bacterium. In this review, we summarise recent advances in our understanding of the mechanisms of intestinal Th17 synthesis in mice, and discuss their relevance to infectious and inflammatory diseases.
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