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CRISPR Gene Editing Tool for MicroRNA Cluster Network Analysis
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[Association of human microRNA related genetic variations with cancer]

Pei-Yao Li1, Fu-Chu He, Gang-Qiao Zhou

  • 1Department of Genomics & Proteomics, State Key Laboratory of Proteomics, Beijing Institute of Radiation Medicine, Beijing 100850, China. lipeiyao214@yahoo.com.cn

Yi Chuan = Hereditas
|August 12, 2011
PubMed

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...
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