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Related Concept Videos

DNA as a Genetic Template02:05

DNA as a Genetic Template

Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
Nucleic Acid Structure01:25

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The pentose sugar in DNA is deoxyribose, while in RNA the pentose sugar is ribose. The difference between the sugars is the presence of the hydroxyl group on the ribose's second carbon and a hydrogen on the deoxyribose's second carbon. The phosphate residue attaches to the hydroxyl group of the 5′ carbon of one sugar and the hydroxyl group of the 3′ carbon of the sugar of the next nucleotide, which forms  a 5′ to 3′ phosphodiester linkage.
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Maxam-Gilbert Sequencing

In the same year as the discovery of the Sanger sequencing method, another group of scientists, Allan Maxam and Walter Gilbert, demonstrated their chemical-cleavage method for DNA sequencing. The Maxam-Gilbert method relies on using different chemicals that can cleave the DNA sequence at specific sites, the separation of resulting DNA fragments of variable size using electrophoresis, and deciphering the DNA sequence from the resulting gel bands.
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The DNA Helix01:07

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Deoxyribonucleic acid, or DNA, is the genetic material responsible for passing traits from generation to generation in all organisms and most viruses. DNA is composed of two strands of nucleotides that wind around each other to form a spring-like structure called a double helix. However, the double helix is not perfectly symmetrical. Instead, there are regularly occurring grooves in the structure. The major groove occurs where the sugar-phosphate backbones are relatively far apart. This space...
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The DNA Helix01:16

The DNA Helix

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Related Experiment Video

Updated: May 30, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
08:59

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Modelling the effect of structure and base sequence on DNA molecular electronics.

M M D Ramos1, H M G Correia

  • 1Departamento de Física, Universidade do Minho, Campus de Gualtar, 4710-057 Braga, Portugal.

Nanotechnology
|August 12, 2011
PubMed
Summary

DNA

Area of Science:

  • Molecular Biophysics
  • Nanotechnology
  • Computational Chemistry

Background:

  • The electronic properties of DNA are crucial for its application in nanoelectronic devices but remain debated.
  • Understanding DNA's conductivity is key to developing novel electronic components.

Purpose of the Study:

  • To investigate how DNA structure and base sequence influence electron addition/removal energies.
  • To analyze charge transfer dynamics along the DNA axis under an electric field.

Main Methods:

  • Utilized a self-consistent quantum molecular dynamics method.
  • Simulated electron injection and charge transport in isolated DNA molecules.

Main Results:

  • Electron addition/removal is most exothermic for poly(dC)-poly(dG) (B-form) and poly(dA)-poly(dT) (A-form).

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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

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Last Updated: May 30, 2026

DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications
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DNA Origami-Mediated Substrate Nanopatterning of Inorganic Structures for Sensing Applications

Published on: September 27, 2019

Analyzing and Building Nucleic Acid Structures with 3DNA
16:24

Analyzing and Building Nucleic Acid Structures with 3DNA

Published on: April 26, 2013

Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles
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Self-assembly of Complex Two-dimensional Shapes from Single-stranded DNA Tiles

Published on: May 8, 2015

  • Electron transfer occurs along the DNA axis irrespective of charge, structure, or sequence.
  • The Z-form exhibited the least exothermic electron addition/removal.

    • Conclusions:

    • Simulation results offer insights not easily obtainable through experiments.
    • Findings are vital for future modeling to enhance charge transport in DNA-based nanoelectronics.