Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Kidney Structure

Kidney Structure

The kidneys are two large bean-shaped organs located in the upper abdomen. They filter the blood several times a day to remove toxins and rebalance water and electrolytes of the circulatory system via the renal veins. The kidneys receive blood directly from the heart via the renal arteries. These arteries enter the kidney at the hilum, the concave surface of the bean, where they branch and divide into smaller vessels and capillaries.

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease I: Introduction

Chronic Kidney Disease (CKD) arises when the kidneys progressively lose their ability to function, ultimately leading to end-stage renal disease. At this advanced stage, the kidneys can no longer filter waste or maintain essential body functions, requiring renal replacement therapy (RRT) through dialysis or a kidney transplant for survival.Early-stage chronic kidney disease and detection challengesIn CKD's early stages, symptoms often remain absent because healthy nephrons compensate for...

Nephrons

Nephrons

The kidneys are intricate organs with millions of working units known as nephrons. Each nephron features two major structures: the renal corpuscle, which facilitates blood plasma filtration, and the renal tubule, which handles the glomerular filtrate. Blood supply is directly linked to the nephrons. The renal corpuscle consists of the glomerulus, a capillary network, and the Bowman's capsule, a double-walled epithelial structure that encases the glomerulus. The filtering of blood plasma happens...

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Excretion

In geriatric patients, renal physiology undergoes significant changes, including diminished renal blood flow and a lower glomerular filtration rate (GFR), leading to alterations in medication clearance. Drugs such as aminoglycoside antibiotics, lithium, and digoxin, which rely on glomerular filtration for removal from the body, particularly impact pharmacokinetics. These drugs tend to have slower clearance rates in older adults, necessitating careful dosage considerations.Evaluation of renal...

Renal Corpuscle

Renal Corpuscle

The glomerulus and Bowman's capsule are two essential components of the nephron, which is the functional unit of the kidney. These microscopic structures play a critical role in the process of blood filtration to produce urine.
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous capillaries...

Acute Kidney Injury II: Pathophysiology

Acute Kidney Injury II: Pathophysiology

Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Facilitated Peer Mentorship for Women Internal Medicine Residents: An Early Intervention to Address Gender Disparities.

Journal of graduate medical education·2023

Same author

Interprofessional geriatric and palliative care intervention associated with fewer hospital days.

Journal of the American Geriatrics Society·2021

Same author

Commentary: Special care considerations in older adults hospitalized with COVID-19.

Aging and health research·2021

Same author

Effect of a Multifactorial Fall Injury Prevention Intervention on Patient Well-Being: The STRIDE Study.

Journal of the American Geriatrics Society·2020

Same author

A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries.

The New England journal of medicine·2020

Same author

Interprofessional Intervention to Improve Geriatric Consultation Timing on an Acute Medical Service.

Journal of the American Geriatrics Society·2018

Search research articles

Related Experiment Video

Updated: May 30, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

Why do our kidneys get old?

Jocelyn Wiggins¹

¹Division of Geriatrics, Internal Medicine, University of Michigan, Ann Arbor, MI 48109, USA. wiggi @ umich.edu

Nephron. Experimental Nephrology

|August 12, 2011

Summary

This summary is machine-generated.

Kidney function naturally declines with age, reducing the ability to handle stress. This review explores aging biology

More Related Videos

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

Related Experiment Videos

Last Updated: May 30, 2026

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Analysis of Nephron Composition and Function in the Adult Zebrafish Kidney

Published on: August 9, 2014

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Estimation of Nephron Number in Whole Kidney using the Acid Maceration Method

Published on: May 22, 2019

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Nephrotoxin Microinjection in Zebrafish to Model Acute Kidney Injury

Published on: July 17, 2016

Area of Science:

Gerontology
Nephrology
Renal Physiology

Background:

Renal clearance and physiologic reserve decrease in most aging humans.
Aging kidneys exhibit reduced capacity to manage physiological challenges like salt or acid loads.

Purpose of the Study:

To investigate the underlying mechanisms of age-related renal function decline.
To explore whether these changes are inevitable or modifiable for preserving kidney function across the lifespan.

Main Methods:

This study is a brief review of aging biology.
It examines the potential impact of aging processes on renal aging.

Main Results:

The specific mechanisms driving age-related decline in renal function remain unclear.
The potential for interventions to preserve renal function throughout aging requires further investigation.

Conclusions:

Age-related decline in renal function is a significant physiological change.
Understanding aging biology is crucial for addressing renal aging and preserving kidney health.