Potential role of serine proteases in modulating renal sodium transport in vivo
G Jacquillet1, I Rubera, R J Unwin
1UCL Centre for Nephrology, Royal Free Hospital, University College London, Medical School, London, UK. g.jacquillet@medsch.ucl.ac.uk
Abstract:
The maintenance of sodium (Na+) homeostasis is an essential function of the kidney. It is achieved by a variety of transport processes localized all along the highly specialised segments of the nephron. Impairment of these transport mechanisms, and thereby Na+ handling, is associated with disturbed Na+ and water balance, leading to hypertension and oedema. This review focuses on the novel regulation of sodium reabsorption by serine proteases acting along the entire nephron.
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