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Updated: May 30, 2026

Bilayer Microfluidic Device for Combinatorial Plug Production
Published on: December 1, 2023
Flexible microfluidic devices with three-dimensional interconnected microporous walls for gas and liquid applications
1Science & Technology, Corning Incorporated, Corning, New York 14831-0001, USA. yuenp@corning.com
Abstract:
This article presents a simple, low-cost method of fabrication and the applications of flexible polystyrene microfluidic devices with three-dimensional (3D) interconnected microporous walls based on treatment using a solvent/non-solvent mixture at room temperature. The complete fabrication process from device design concept to working device can be completed in less than an hour in a regular laboratory setting, without the need for expensive equipment. Microfluidic devices were used to demonstrate gas generation and absorption reactions by acidifying water with carbon dioxide (CO(2)) gas. By selectively treating the microporous structures with oxygen plasma, acidification of water by acetic acid (distilled white vinegar) perfusion was also demonstrated with the same device design.

