Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...

MicroRNAs

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA ends...

Neuroplasticity

Neuroplasticity

Neuroplasticity reflects the brain's remarkable capacity to adapt and evolve, responding dynamically to learning, experiences, or injury by reorganizing its neural circuitry. This reorganization involves creating new neural connections and refining old ones through a series of biological processes that contribute to the brain's lifelong development and adaptability.

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Integrative transcriptomics and electrophysiological profiling of hiPSC-derived neurons identifies novel druggable pathways in Koolen-de Vries Syndrome.

Molecular psychiatry·2026

Same author

HGprt deficiency disrupts dopaminergic circuit development in a genetic mouse model of Lesch-Nyhan disease.

Cellular and molecular life sciences : CMLS·2022

Same author

Transduction profiles in minipig following MRI guided delivery of AAV-5 into thalamic and corona radiata areas.

Journal of neuroscience methods·2021

Same author

Antioxidant treatment ameliorates prefrontal hypomyelination and cognitive deficits in a rat model of schizophrenia.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology·2021

Same author

Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips.

Scientific reports·2021

Same author

De novo variants in MED12 cause X-linked syndromic neurodevelopmental disorders in 18 females.

Genetics in medicine : official journal of the American College of Medical Genetics·2020

Search research articles

Related Experiment Video

Updated: May 30, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

MicroRNA networks direct neuronal development and plasticity.

N F M Olde Loohuis¹, A Kos, G J M Martens

¹Department of Cognitive Neuroscience, Radboud University Nijmegen, 6500 HB Nijmegen, The Netherlands.

Cellular and Molecular Life Sciences : CMLS

|August 12, 2011

Summary

MicroRNAs (miRNAs) are small RNAs regulating gene expression in neurons. Dysregulation of these neural miRNAs impacts brain development, synaptic plasticity, and neurological disease pathology.

More Related Videos

Generating and Co-culturing Murine Primary Microglia and Cortical Neurons

Generating and Co-culturing Murine Primary Microglia and Cortical Neurons

Published on: July 26, 2024

Related Experiment Videos

Last Updated: May 30, 2026

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Differentiation of a Human Neural Stem Cell Line on Three Dimensional Cultures, Analysis of MicroRNA and Putative Target Genes

Published on: April 12, 2015

Generating and Co-culturing Murine Primary Microglia and Cortical Neurons

Generating and Co-culturing Murine Primary Microglia and Cortical Neurons

Published on: July 26, 2024

Area of Science:

Neuroscience
Molecular Biology
Genetics

Background:

MicroRNAs (miRNAs) are key post-transcriptional gene regulators.
Neural miRNAs play crucial roles in neuronal development and maturation.
miRNAs are involved in processes like neurite outgrowth, dendritogenesis, and spine formation.

Purpose of the Study:

To provide an overview of miRNA functions in neuronal development and plasticity.
To explore the consequences of miRNA dysregulation in neurological disorders.

Main Methods:

Review of recent studies on neural miRNA mechanisms.
Analysis of miRNA roles in neuronal development and synaptic plasticity.
Discussion of miRNA dysregulation in the context of neurological diseases.

Main Results:

miRNAs are locally translated in neuronal compartments, organizing axonal and dendritic structures.
Altered miRNA expression is implicated in neurological disorder pathology.
miRNAs are critical for both early brain development and later synaptic plasticity.

Conclusions:

miRNAs are essential regulators of neuronal development and plasticity.
Understanding miRNA dysregulation offers insights into neurological disorders.
Further research into neural miRNAs is vital for understanding brain function and disease.