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RNAi pathway integration in Caenorhabditis elegans development

Sadegh Azimzadeh Jamalkandi1, Ali Masoudi-Nejad

  • 1Laboratory of Systems Biology and Bioinformatics, Institute of Biochemistry and Biophysics and COE in Biomathematics, University of Tehran, Iran.

Functional & Integrative Genomics
|August 12, 2011
PubMed

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...