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Updated: May 30, 2026

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Perfusion-weighted MR imaging in persistent hemiplegic migraine.

Isabelle Mourand¹, Nicolas Menjot de Champfleur, Clarisse Carra-Dallière

¹Service de Neuroradiologie, Hôpital Gui de Chauliac, 80 avenue Augustin Fliche, 34295, Montpellier Cedex 5, France. i-mourand@chu-montpellier.fr

|August 12, 2011

Summary

Perfusion-weighted imaging (PWI) detected temporary cerebral blood flow changes during hemiplegic migraine attacks. These hemodynamic alterations resolved spontaneously, aiding in understanding migraine pathogenesis.

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Area of Science:

Neurology
Radiology
Neuroimaging

Background:

Hemiplegic migraine, a rare variant, presents with motor weakness during aura.
The underlying pathogenesis of migraine remains incompletely understood.
Perfusion-weighted imaging (PWI) offers a non-invasive method to study cerebral hemodynamics during migraine attacks.

Observation:

Two female patients with prolonged hemiparesis underwent 1.5 T MRI with diffusion-weighted and perfusion imaging.
Regions of interest were analyzed for flow index, cerebral blood volume, mean transit time, and time to peak.
Asymmetry indices were calculated for each perfusion parameter.

Findings:

PWI revealed perfusion alterations during hemiplegic migraine attacks.
One patient showed hypoperfusion in the contralateral hemisphere after 3 hours of hemiparesis.
Another patient exhibited hyperperfusion in the ipsilateral hemisphere during a familial hemiplegic migraine with persistent aura.
Asymmetry indices for temporal parameters (mean transit time, time to peak) were most sensitive.
All perfusion changes resolved spontaneously without sequelae or ischemic signs on follow-up MRI.

Implications:

PWI is valuable for assessing sequential changes in cerebral perfusion during hemiplegic migraine.
This technique can enhance the understanding of migraine pathogenesis.
PWI may aid in the diagnosis and management of complex migraine presentations.