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Related Experiment Video

Updated: May 30, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Targeting bone as a therapy for myeloma.

Ping Wu¹, Gareth J Morgan

¹Section of Haemato-Oncology, Institute of Cancer Research, 15 Cotswold Road, Sutton, Surrey, SM2 5NG, UK.

Cancer Microenvironment : Official Journal of the International Cancer Microenvironment Society

|August 12, 2011

Summary

Myeloma bone disease negatively impacts survival and quality of life. Targeting the bone microenvironment, including osteoclasts and osteoblasts, offers therapeutic strategies against myeloma.

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Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

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Last Updated: May 30, 2026

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Multimodal Bioluminescent and Positronic-emission Tomography/Computational Tomography Imaging of Multiple Myeloma Bone Marrow Xenografts in NOG Mice

Published on: January 7, 2019

Models of Bone Metastasis

Models of Bone Metastasis

Published on: September 4, 2012

Area of Science:

Oncology
Bone Biology
Cancer Therapeutics

Background:

Myeloma bone disease (BD) significantly impairs patient quality of life and survival.
The imbalance of osteoclast and osteoblast activity is crucial for myeloma tumor growth and expansion.
Myeloma cell survival is intrinsically linked to interactions within the bone microenvironment.

Purpose of the Study:

To review recent advancements in understanding the biology of myeloma bone disease.
To highlight the roles of osteoclasts and osteoblasts in myeloma pathogenesis.
To discuss therapeutic strategies targeting myeloma-bone interactions.

Main Methods:

Review of current literature on myeloma bone disease biology.
Analysis of experimental and clinical findings on bone-targeted therapies.
Synthesis of information on osteoclast and osteoblast function in myeloma.

Main Results:

Bone-targeted therapies improve myeloma bone disease and patient outcomes.
Modulating osteoclast and osteoblast activity creates an unfavorable environment for myeloma cells.
Understanding myeloma-bone interactions is key to developing new treatments.

Conclusions:

Targeting the bone microenvironment is a promising therapeutic approach for multiple myeloma.
Further research into myeloma-bone interactions will drive the development of novel treatments for BD.
Improving the management of myeloma bone disease is expected to enhance overall clinical outcomes for myeloma patients.