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Updated: May 30, 2026
07:34
Establishment of a Modified Ferric Chloride-Induced Superior Sagittal Sinus Thrombosis
Published on: December 30, 2025
Anticoagulation for cerebral venous sinus thrombosis.
Jonathan Coutinho1, Sebastiaan Ftm de Bruijn, Gabrielle Deveber
1Department of Neurology, Academic Medical Centre, University of Amsterdam, PO Box 22700, Amsterdam, Netherlands, 1100 DE.
The Cochrane Database of Systematic Reviews
|August 12, 2011
Summary
Anticoagulant therapy for cerebral venous sinus thrombosis (CVST) appears safe, potentially reducing death or dependency. However, limited evidence from two trials necessitates further research to confirm these findings in CVST patients.
Area of Science:
- Neurology
- Vascular Medicine
- Thrombosis Research
Background:
- Cerebral venous sinus thrombosis (CVST) treatment with anticoagulants remains controversial.
- Anticoagulants may prevent new venous infarcts and neurologic deterioration but carry a risk of hemorrhage.
Purpose of the Study:
- To assess the effectiveness and safety of anticoagulant therapy in patients with confirmed cerebral venous sinus thrombosis.
Main Methods:
- Searched multiple databases (Cochrane Stroke Group, MEDLINE, EMBASE, CENTRAL) up to August 2010.
- Included unconfounded randomized controlled trials comparing anticoagulants with placebo or open control for CVST.
- Performed intention-to-treat analysis and calculated pooled relative risks and absolute risk reductions.
Main Results:
- Two small trials (79 patients) evaluated unfractionated heparin and low-molecular-weight heparin.
- Anticoagulant therapy showed a pooled relative risk of death of 0.33 (95% CI 0.08 to 1.21).
- Associated with a 13% absolute risk reduction in death or dependency (95% CI 30% to -3%), with one major GI hemorrhage observed.
Conclusions:
- Limited evidence suggests anticoagulant treatment for CVST is safe.
- A potentially important reduction in death or dependency risk was observed but did not reach statistical significance.
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