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In Vitro Fertilization

In Vitro Fertilization

In vitro fertilization (IVF) is a form of assisted reproductive technology where an egg is fertilized with sperm in a controlled laboratory environment before transferring the resulting embryo into the uterus. This process is designed to help individuals and couples experiencing difficulties conceiving.
The IVF process begins with ovarian stimulation, during which reproductive endocrinologists prescribe hormonal medications to stimulate the ovaries to produce multiple eggs instead of the single...

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Related Experiment Video

Updated: May 30, 2026

Human Blastocyst Biopsy and Vitrification

Human Blastocyst Biopsy and Vitrification

Published on: July 26, 2019

Aspirin for in vitro fertilisation.

Charalambos S Siristatidis¹, Susanna R Dodd, Andrew J Drakeley

¹3rd Department of Obstetrics & Gynaecology, University of Athens, Assisted Reproduction Unit, Attikon University Hospital, Rimini 1, Chaidari, Athens, Greece, 12462.

The Cochrane Database of Systematic Reviews

|August 12, 2011

Summary

Aspirin use in in vitro fertilization (IVF) shows no significant benefit for live birth or pregnancy rates. Current evidence does not support its recommendation for IVF outcomes.

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Area of Science:

Reproductive Medicine
Obstetrics & Gynecology

Background:

Aspirin (acetylsalicylic acid) is frequently used to enhance outcomes in assisted reproductive technologies.
Evidence supporting its efficacy in in vitro fertilization (IVF) remains inconsistent.
Optimal timing and duration for aspirin therapy in IVF are not established.

Purpose of the Study:

To evaluate the effectiveness and safety of aspirin in improving outcomes for IVF and intracytoplasmic sperm injection (ICSI) cycles.

Main Methods:

Comprehensive search of multiple databases (Cochrane, MEDLINE, EMBASE) for randomized controlled trials.
Inclusion criteria focused on randomized controlled trials of aspirin in women undergoing IVF.
Data extraction and quality assessment were performed independently by two authors.

Main Results:

Thirteen trials involving 2653 participants were included.
No significant differences were observed in live birth rates (RR 0.91) or clinical pregnancy rates (RR 1.03) between aspirin and control groups.
Ectopic and miscarriage rates also showed no statistically significant differences.

Conclusions:

Current trial data do not provide sufficient evidence to recommend aspirin for women undergoing IVF.
Larger, adequately powered trials are necessary to determine any potential benefits.
Until further evidence is available, aspirin use in IVF cannot be recommended.