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Related Experiment Video

Updated: May 30, 2026

Isolation and Analysis of Plasma Lipoproteins by Ultracentrifugation
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Published on: January 28, 2021

Lipid apheresis, indications, and principles.

Jeffrey L Winters1

  • 1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA. winters.jeffrey@mayo.edu

Journal of Clinical Apheresis
|August 12, 2011
PubMed
Summary

Low-density lipoprotein apheresis (LDL apheresis) removes harmful lipoproteins to treat familial hypercholesterolemia (FH). This review details FH, LDL apheresis mechanisms, and its treatment applications.

Area of Science:

  • Cardiovascular Medicine
  • Metabolic Disorders
  • Medical Technology

Background:

  • Familial hypercholesterolemia (FH) is an inherited disorder causing severe hyperlipidemia and premature atherosclerosis.
  • Accelerated atherosclerosis in FH leads to significant coronary artery disease and early mortality.
  • Current treatments for FH often require lifelong management to mitigate cardiovascular risk.

Purpose of the Study:

  • To review the pathophysiology of familial hypercholesterolemia (FH).
  • To describe the mechanisms of action for various low-density lipoprotein apheresis (LDL apheresis) devices.
  • To outline the therapeutic applications of LDL apheresis in managing FH.

Main Methods:

  • Selective removal of apolipoprotein B-containing lipoproteins using apheresis technology.

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  • Review of existing literature on LDL apheresis devices and their efficacy.
  • Analysis of clinical data regarding LDL apheresis in FH patients.

    • Main Results:

    • LDL apheresis effectively reduces low-density lipoprotein cholesterol levels.
    • Various apheresis devices demonstrate consistent efficacy in lipoprotein removal.
    • LDL apheresis is a proven treatment for FH, reducing cardiovascular event risk.

    Conclusions:

    • LDL apheresis is a critical therapeutic option for managing familial hypercholesterolemia.
    • Understanding apheresis mechanisms is key to optimizing treatment strategies.
    • Further research may expand the role of LDL apheresis in other lipid disorders.