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Encapsulation of docetaxel into PEGylated gold nanoparticles for vectorization to cancer cells
Alison François1, Audrey Laroche, Noël Pinaud
1Institut des Sciences Moléculaires, UMR CNRS 5255, Université Bordeaux I, 351 Cours de la Libération, 33405 Talence Cedex, France.
Abstract:
Encapsulation of docetaxel and its solubilization in water was carried out in PEGylated gold nanoparticles (AuNPs) as shown by 1H NMR (600 MHz) and UV/Vis spectroscopy and dynamic light scattering. Vectorization of PEGylated AuNP-encapsulated docetaxel was probed in vitro toward human colon carcinoma (HCT15) and human breast cancer (MCF7) cells. AuNPs alone presented no cytotoxicity toward either MCF7 or HCT15 adenocarcinoma cells. AuNP-docetaxel was found to be 2.5-fold more efficient than docetaxel alone against MCF7 cells, and the IC50 value of AuNP-docetaxel against HCT15 cells was lower than that of free docetaxel; the increased efficiency brought about by AuNP drug encapsulation was ∼1.5-fold.
