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Updated: May 30, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

[Hypophosphatemia in critically ill patients].

T Nguyen¹, J L Vincent

¹Service des Soins Intensifs, Hôpital Erasme.

Revue Medicale De Bruxelles

|August 13, 2011

Summary

Hypophosphatemia, low phosphorus levels, is common in critically ill patients. Severe cases impact multiple body systems and require prompt correction to prevent complications.

Area of Science:

Biochemistry
Critical Care Medicine
Human Physiology

Background:

Phosphorus is a vital mineral element crucial for cellular function.
Hypophosphatemia, characterized by low phosphorus levels, is frequently observed in critically ill patient populations.
This condition can arise from various factors including renal excretion, digestive absorption issues, intracellular shifts, and severe catabolism.

Purpose of the Study:

To summarize the causes, clinical manifestations, and management of hypophosphatemia.
To highlight the significance of phosphorus in cellular processes.
To emphasize the need for correction in symptomatic and severe hypophosphatemia.

Main Methods:

Literature review of phosphorus metabolism and hypophosphatemia.

Related Experiment Videos

Last Updated: May 30, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses

Published on: August 30, 2018

Analysis of clinical data related to critically ill patients with phosphorus imbalances.

Synthesis of information on the physiological impact of low phosphorus levels.

Main Results:

Hypophosphatemia stems from increased renal excretion, reduced absorption, intracellular shifts, or catabolic states.
Severe hypophosphatemia presents with significant impairments in respiratory, musculoskeletal, pulmonary, and neurological systems.
The prevalence of hypophosphatemia is notably high among individuals in intensive care settings.

Conclusions:

Prompt correction of hypophosphatemia is essential, particularly in severe and symptomatic cases.
Understanding the multifactorial causes and systemic effects is key to effective patient management.
Maintaining adequate phosphorus levels is critical for cellular viability and overall patient recovery.