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Updated: May 30, 2026

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides
07:50

Efficient Synthesis of All-Carbon Quaternary Centers via the Conjugate Addition of Functionalized Monoorganozinc Bromides

Published on: May 26, 2019

Highly efficient one-pot access to functionalized arylboronic acids via noncryogenic bromine/magnesium exchanges

Timo Leermann1, Frédéric R Leroux, Françoise Colobert

  • 1Laboratoire de Stéréochimie (UMR CNRS 7509), CNRS/Université de Strasbourg (ECPM), 25 Rue Becquerel, F-67087 Strasbourg, France.

Organic Letters
|August 13, 2011
PubMed
Summary

A new method simplifies the synthesis of aryl boronic acids using aryl Grignard reagents. This convenient protocol achieves excellent yields at 0 °C, offering a straightforward approach for various compounds.

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