Neurogenic ejaculatory disorders: focus on current and future treatments

Area of Science:

• Neuroscience
• Urology
• Sexual Medicine

Background:

• Ejaculation is a complex neurological reflex, poorly understood at spinal and cerebral levels.
• Premature ejaculation (PE) is common, often psychogenic but linked to urological/neurological diseases.
• Retrograde ejaculation and anejaculation are typically neurogenic; ejaculatory disorders are frequent in spinal cord injury.

Purpose of the Study:

• To comprehensively review current and emerging treatments for neurogenic ejaculatory disorders.
• To explore assigned patents for future therapeutic strategies.
• To address less-investigated conditions like painful ejaculation.

Main Methods:

• Literature review of clinical studies and research on ejaculatory mechanisms.
• Analysis of treatment efficacy for premature ejaculation (PE) and other ejaculatory disorders.
• Examination of neurogenic causes and their impact on ejaculatory function.

Main Results:

• Antidepressants show efficacy in treating premature ejaculation (PE).
• Neurogenic causes significantly impact ejaculatory function, especially in spinal cord injury.
• Therapies for other ejaculatory disorders, like painful ejaculation, remain controversial and less researched.

Conclusions:

• Neurogenic ejaculatory disorders require targeted therapeutic approaches.
• Further research is needed for conditions beyond PE, particularly painful ejaculation.
• Understanding the neurological basis of ejaculation is crucial for developing effective treatments and exploring patented therapies.