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Updated: May 30, 2026
07:36
Isolation of Human Lymphatic Endothelial Cells by Multi-parameter Fluorescence-activated Cell Sorting
Published on: May 1, 2015
Lymphatic malformations: clinical course and management in 64 cases
Marcia Hogeling1, Susan Adams, Jenaleen Law
1Department of Paediatric Dermatology, UNSW School of Women's and Children's Health, Sydney Children's Hospital, Sydney, NSW, Australia. hogelingm@yahoo.ca
The Australasian Journal of Dermatology
|August 13, 2011
Summary
Lymphatic malformations (LM) are diverse vascular anomalies causing significant illness in children, often diagnosed late. Management requires a coordinated team approach for best outcomes.
Area of Science:
- Pediatric vascular anomalies
- Congenital malformations
- Medical genetics
Background:
- Lymphatic malformations (LM) are uncommon congenital vascular anomalies.
- These malformations can lead to substantial patient morbidity.
Purpose of the Study:
- To characterize the clinical presentation of pediatric lymphatic malformations.
- To define the management strategies for children diagnosed with LM.
Main Methods:
- Retrospective analysis of patient charts for children with LM.
- Inclusion of parent telephone interviews to gather comprehensive data.
- Recording of demographic, clinical, imaging, treatment, and complication details.
Main Results:
- Head and neck region was the most common LM site (48%), predominantly on the left (62%).
- Macrocystic LM (60%) were most frequent, presenting as swelling; 70% of patients experienced morbidity.
- Treatments included sclerotherapy (sodium tetradecyl sulfate, OK-432, doxycycline), surgery, or no intervention.
Conclusions:
- LM are heterogeneous vascular malformations with significant morbidity potential.
- Diagnosis of LM is frequently delayed.
- A multidisciplinary management approach involving dermatology, radiology, and pediatric surgery is crucial.
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