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Related Concept Videos

Multiple Sclerosis l: Introduction01:19

Multiple Sclerosis l: Introduction

Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
Muscles that Move the Leg01:23

Muscles that Move the Leg

The movement of the legs is facilitated by numerous muscles located within the anterior, medial, and posterior compartments of the thigh.
Anterior Compartment
The quadriceps femoris, the most visible muscle of the anterior compartment, is integral for leg extension and thigh flexion. It is formed by merging four distinct muscles — the vastus lateralis, vastus medialis, vastus intermedius, and rectus femoris. The quadriceps tendon, a shared tendon of the four quadriceps muscles, is affixed to...

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Related Experiment Video

Updated: May 30, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
08:48

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Published on: January 29, 2016

Pseudo-quadriceps sparing in multiple sclerosis.

N Levin1, A Vaknin-Dembinsky, P Petrou

  • 1Department of Neurology and the Agnes-Ginges Center for Neurogenetics, Hadassah-Hebrew University Hospital, Jerusalem, Israel.

European Journal of Neurology
|August 13, 2011
PubMed
Summary
This summary is machine-generated.

In multiple sclerosis (MS), the quadriceps muscle is notably spared despite significant weakness in the iliopsoas muscle. This finding offers insights into MS motor disability assessment.

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The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
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Related Experiment Videos

Last Updated: May 30, 2026

Adapted Resistance Training Improves Strength in Eight Weeks in Individuals with Multiple Sclerosis
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Published on: January 29, 2016

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve
09:51

The Transition to an Anterior-Based Muscle Sparing Approach Improves Early Postoperative Function but is Associated with a Learning Curve

Published on: September 7, 2022

Area of Science:

  • Neurology
  • Muscle Physiology

Background:

  • Differential muscle involvement is observed in various myopathies.
  • Such specific muscle group involvement patterns have not been previously described in multiple sclerosis (MS) or general pyramidal syndromes.

Purpose of the Study:

  • To investigate the differential involvement of distinct muscle groups in patients with chronic pyramidal syndrome caused by MS.
  • To compare muscle power in the quadriceps and iliopsoas muscles in MS patients.

Main Methods:

  • Muscle power was assessed in 127 patients with chronic MS-related pyramidal syndrome.
  • A control group of 37 patients with acute or chronic paraparesis from other causes was included for comparison.

Main Results:

  • Patients with MS showed significantly weaker iliopsoas muscles (1.68±1.1) compared to their quadriceps muscles (4.06±1.4).
  • The control group exhibited no significant difference in muscle power between the iliopsoas (2±1.2) and quadriceps (2.4±1.4) muscles.

Conclusions:

  • The quadriceps muscle remains relatively spared in MS patients, even with severe, long-standing paraparesis.
  • Potential neuroanatomical, neurophysiological, and rehabilitational factors may explain this sparing.
  • This observation could lead to improved scales for assessing motor disability and disease progression in MS.