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Partial response to anakinra in life-threatening Henoch-Schönlein purpura: case report
Erynn M Boyer1, Martin Turman, Kathleen M O'Neil
1Division of Rheumatology, Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA. kathleen-oneil@ouhsc.edu.
Abstract:
Henoch-Schönlein purpura is one of the most common forms of systemic vasculitis of childhood. We report the response to anakinra, the interleukin-1 receptor antagonist, in a 9 year old girl without prior medical problems who developed life-threatening Henoch-Schönlein vasculitis that produced renal failure, pulmonary hemorrhage and vasculitis of the brain. Her response supports the theory that interleukin-1 may be an important mediator in this disease. Further study of interleukin-1 antagonists in severe Henoch-Schönlein purpura may be warranted.
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