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[Perspectives on therapy with diphosphonates in non-malignant diseases]
1Medizinische Abteilung, Ludwig-Boltzmann-Institut für Altersforschung, Wien, Osterreich.
Zeitschrift Fur Gerontologie
|January 1, 1990
Summary
Diphosphonates are effective in treating bone diseases like Paget's and osteoporosis by inhibiting bone resorption. Newer formulations are preferred for Paget's disease due to safety concerns with older types.
Area of Science:
- Pharmacology
- Orthopedics
- Endocrinology
Context:
- Diphosphonates are a class of drugs known for inhibiting bone resorption.
- Their therapeutic effects have been recognized in various bone-related conditions.
- The evolution of diphosphonate formulations has improved their safety and efficacy profiles.
Purpose:
- To review the therapeutic applications and efficacy of diphosphonates in managing bone resorption disorders.
- To highlight the role of diphosphonates in treating Paget's disease, osteoporosis, and other bone pathologies.
- To discuss the prophylactic and therapeutic benefits of diphosphonates in diverse clinical scenarios.
Summary:
- Diphosphonates effectively inhibit osteoclast activity, reducing bone resorption.
- They are utilized in treating Paget's disease, with newer agents like APD and clodronate preferred over EHDP.
- Efficacy is demonstrated in high-turnover osteoporosis, steroid-induced osteoporosis, and immobilization osteoporosis.
- Prophylactic use is considered in post-menopausal women with contraindications to estrogen therapy and in Gaucher's disease.
- Potential applications include preventing ectopic ossification in orthopedic procedures.
Impact:
- Diphosphonates have significantly impacted the management of metabolic bone diseases.
- They offer therapeutic and prophylactic benefits, improving bone mass and reducing fracture risk.
- Ongoing research may expand their use in orthopedic and other related fields.