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Related Experiment Video

Updated: May 30, 2026

Generation of Aggregates of Mouse Embryonic Stem Cells that Show Symmetry Breaking, Polarization and Emergent Collective Behaviour In Vitro

Generation of Aggregates of Mouse Embryonic Stem Cells that Show Symmetry Breaking, Polarization and Emergent Collective Behaviour In Vitro

Published on: November 24, 2015

Semaphorin breaks symmetry.

Audrey S Howell¹, Kang Shen

¹Howard Hughes Medical Institute, Department of Biology, Stanford University, Stanford, CA 94305, USA.

|August 13, 2011

Summary

This summary is machine-generated.

Semaphorin 3A, an axon guidance cue, promotes dendrite growth by inhibiting axon specification. This finding sheds light on how developing neurons establish correct axon-dendrite polarity.

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Area of Science:

Neuroscience
Developmental Biology

Background:

Axon-dendrite polarity is crucial for neural circuit formation.
Extrinsic cues are thought to guide this process, but mechanisms are unclear.

Discussion:

Shelly et al. demonstrate Semaphorin 3A's novel role in regulating neuronal polarity.
The study reveals how axon guidance molecules can influence dendrite development.

Key Insights:

Semaphorin 3A inhibits axon specification, thereby promoting dendrite growth.
This provides a new mechanism for establishing axon-dendrite asymmetry.

Outlook:

Further research can explore other guidance cues in polarity determination.
Understanding these mechanisms could inform therapeutic strategies for neurological disorders.