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Related Experiment Video

Updated: May 30, 2026

Murine Endoscopy for In Vivo Multimodal Imaging of Carcinogenesis and Assessment of Intestinal Wound Healing and Inflammation

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Published on: August 26, 2014

Capsule endoscopy in nonresponsive celiac disease.

David S Atlas¹, Alberto Rubio-Tapia, Carol T Van Dyke

¹Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.

Gastrointestinal Endoscopy

|August 13, 2011

Summary

This summary is machine-generated.

Capsule endoscopy (CE) can identify mucosal abnormalities in patients with nonresponsive celiac disease (CD) and detect severe complications. This diagnostic tool is useful for evaluating persistent symptoms despite a gluten-free diet (GFD).

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Area of Science:

Gastroenterology
Digestive Endoscopy
Celiac Disease Research

Background:

Nonresponsive celiac disease (CD) presents with persistent or recurrent symptoms despite adherence to a gluten-free diet (GFD).
Evaluating the small intestine is crucial for diagnosing and managing CD complications.

Purpose of the Study:

To assess the diagnostic utility of capsule endoscopy (CE) in identifying mucosal abnormalities in patients with nonresponsive CD.
To determine the effectiveness of CE in detecting severe complications associated with nonresponsive CD.

Main Methods:

A case-control study was conducted at a tertiary-care center.
Forty-two patients with nonresponsive CD and 84 CD-free controls underwent capsule endoscopy (CE).
Retrospective evaluation of CE in 30 patients with uncomplicated CD on a GFD was also performed.

Main Results:

CE detected macroscopic villous atrophy in 31% of nonresponsive CD patients and 47% of uncomplicated CD patients.
The sensitivity and specificity of CE for detecting villous atrophy were 56% and 85%, respectively.
CE identified severe complications, including ulcerative jejunitis and adenocarcinoma, in nonresponsive CD patients.

Conclusions:

Capsule endoscopy (CE) reveals mucosal abnormalities in both nonresponsive and uncomplicated celiac disease (CD).
CE is valuable for detecting significant gastrointestinal complications in patients with nonresponsive CD.
The findings support the use of CE in the workup of nonresponsive CD.