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Related Experiment Video

Updated: May 30, 2026

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

Published on: April 18, 2019

Dosing of colistin-back to basic PK/PD.

Phillip J Bergen¹, Jian Li, Roger L Nation

¹Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Melbourne, Australia.

Current Opinion in Pharmacology

|August 13, 2011

Summary

Colistin methanesulfonate (CMS) is crucial for treating multidrug-resistant Gram-negative infections. Current CMS dosage guidelines are suboptimal, leading to treatment failures and resistance, especially in critically ill patients.

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Antimicrobial Synergy Testing by the Inkjet Printer-assisted Automated Checkerboard Array and the Manual Time-kill Method

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Published on: April 18, 2019

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Published on: October 11, 2024

Area of Science:

Pharmacology
Infectious Diseases
Critical Care Medicine

Background:

Rising multidrug-resistant Gram-negative bacteria necessitates re-evaluating colistin.
Colistin methanesulfonate (CMS) is a vital salvage therapy for difficult infections.
Current CMS dosage guidelines lack scientific basis, leading to adverse outcomes.

Purpose of the Study:

To review recent advancements in understanding CMS and colistin pharmacokinetics and pharmacodynamics.
To emphasize the implications for critically ill patients.
To inform the design of optimal colistin dosage regimens.

Main Methods:

Review of recent pharmacokinetic and pharmacodynamic data for CMS and colistin.
Focus on critically ill patient populations.
Analysis of the PK/PD relationship to guide dosing.

Main Results:

Current CMS dosage regimens are frequently suboptimal in critically ill patients.
Emerging data highlight the need for evidence-based dosing strategies.
Understanding PK/PD is key to improving colistin efficacy.

Conclusions:

Optimizing colistin methanesulfonate (CMS) dosing is critical for effective treatment of multidrug-resistant Gram-negative infections.
Evidence-based pharmacokinetics and pharmacodynamics are essential for improving patient outcomes.
Revised dosing strategies are needed to combat treatment failure and resistance.