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Updated: May 30, 2026
10:35
Extracellular Glucose Depletion as an Indirect Measure of Glucose Uptake in Cells and Tissues Ex Vivo
Published on: April 6, 2022
[Questions in diabetology to be elucidated]
Kornél Simon1, Edit Dobó, Anikó Szépvölgyi
1Siófok Város Kórház-Rendelőintézete, Belgyógyászati Osztály, Siófok. kornelsimon@datatrans.hu
Orvosi Hetilap
|August 13, 2011
Summary
Chronic stress and lifestyle choices significantly increase cardiovascular disease risk, often linked to obesity and type 2 diabetes. Addressing these root causes, rather than just risk factors, is crucial for effective prevention and management.
Area of Science:
- Cardiology
- Endocrinology
- Public Health
Background:
- Cardiovascular disease (CVD) incidence is rising globally, linked to urbanization, obesity, and type 2 diabetes.
- Modern therapeutic strategies for CVD risk reduction are criticized for focusing on risk factors rather than primary causes.
- Chronic stress and lifestyle are identified as primary drivers of CVD risk, with risk factors being secondary consequences.
Purpose of the Study:
- To detail the association between lifestyle, chronic stress, and increased cardiovascular risk.
- To critique current therapeutic policies for cardiovascular risk management.
- To emphasize the primary causal role of chronic stress and lifestyle in CVD pathogenesis.
Main Methods:
- Review and analysis of existing literature on CVD, chronic stress, obesity, and type 2 diabetes.
- Discussion of the pathogenesis of macro- and microangiopathy in relation to chronic stress.
- Examination of clinical and experimental data on dysmetabolism and its role in metabolic syndrome and type 2 diabetes.
Main Results:
- Chronic stress and lifestyle are primary etiological factors in cardiovascular risk.
- Current management approaches focusing on risk factors have limited value compared to addressing root causes.
- Non-ischemic diabetic cardiomyopathy is an independent risk factor in diabetes-related cardiovascular risk.
- Management of hypertension and dyslipidemia is more effective than hyperglycemia control in reducing CVD risk in diabetics.
Conclusions:
- Targeting chronic stress and lifestyle is essential for effective CVD prevention and management.
- Addressing dysmetabolism is critical for eliminating excessive cardiovascular risk in diabetes.
- Metabolic promoters may play a role in managing dysmetabolism and reducing overall cardiovascular risk.
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