Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Adrenal Gland Disorders01:27

Adrenal Gland Disorders

Adrenal gland disorders manifest when the production of adrenal hormones deviates from the norm, resulting in either excessive or insufficient concentrations.
Adrenal insufficiency, characterized by insufficient cortisol and aldosterone production, leads to conditions like Addison's disease. This disorder, affecting the adrenal cortex, exhibits symptoms such as skin bronzing, dehydration, low blood pressure, fatigue, and weight loss. Congenital adrenal hyperplasia, a genetic ailment causing...
Signs of Puberty01:27

Signs of Puberty

Puberty is a critical phase, typically beginning between the ages of 8 and 13 in girls and 9 and 14 in boys, though timing can vary based on genetics, environmental factors, and overall health. This period is characterized by the development of secondary sexual characteristics and the attainment of reproductive potential. Endocrine changes underpin puberty, with hormonal surges of Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH) instigated by Gonadotropin-Releasing Hormone (GnRH)...
Attention-Deficit/Hyperactivity Disorder01:30

Attention-Deficit/Hyperactivity Disorder

Attention-deficit/hyperactivity disorder (ADHD) is a neurodevelopmental disorder characterized by persistent inattention, hyperactivity, and impulsivity. It affects approximately 5-8% of children globally, with around 60-70% of cases persisting into adulthood. ADHD has significant implications for educational attainment, social interactions, and occupational success.
Diagnostic Criteria and Symptoms
To diagnose ADHD, symptoms must manifest before age 12 and be evident across multiple settings.
Hormones of the Adrenal Glands01:31

Hormones of the Adrenal Glands

Adrenal hormones play a pivotal role in maintaining the body's electrolyte balance and orchestrating responses to stress, showcasing the intricate functions of the adrenal cortex and medulla.
The adrenal cortex, a powerhouse of hormone synthesis, generates over two dozen corticosteroid hormones. The zona glomerulosa produces mineralocorticoids, exemplified by aldosterone, influencing the electrolyte composition of body fluids. The synthesis of glucocorticoids such as cortisol and corticosterone...
Cushing Syndrome II: Pathophysiology01:19

Cushing Syndrome II: Pathophysiology

Cortisol production is normally governed by the hypothalamic–pituitary–adrenal (HPA) axis, which maintains hormonal balance through tightly regulated feedback mechanisms. Disruption of this regulatory system is central to the development of Cushing syndrome, whether the excess cortisol originates from external medications or internal pathology. Persistent cortisol elevation alters metabolism, immune function, and endocrine signaling, producing the characteristic clinical features of the...
Cushing Syndrome I: Introduction01:26

Cushing Syndrome I: Introduction

Cushing syndrome refers to the collection of clinical manifestations that arise when tissues are exposed to excessive amounts of cortisol or cortisol-like medications over an extended period. Cortisol, a glucocorticoid produced by the adrenal cortex, regulates metabolism, immune responses, and the body’s adaptation to stress. When its concentration remains chronically elevated, these physiological pathways become dysregulated, resulting in the characteristic features of the syndrome.Exogenous...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Prehospital Factors Associated with Low-Acuity Status Among Pediatric Emergency Medical Services Transports in a Multicenter EMS Sample.

Academic pediatrics·2026
Same author

Nonemergency Acute Care Delivered Outside of the Medical Home: Policy Statement.

Pediatrics·2026
Same author

Reduced cortical thickness in individuals with congenital adrenal hyperplasia (CAH).

Scientific reports·2026
Same author

Are EMS Systems Ready to Meet the Needs of Children With Medical Complexity?

Pediatrics·2026
Same author

Effective Community Consultation for Prehospital EFIC Research: Lessons from a 20-Site Pediatric Trial.

Prehospital emergency care·2026
Same author

The inverse association between circulatory placental biomarkers in early pregnancy and maternal body mass index.

Placenta·2026

Related Experiment Video

Updated: May 30, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Premature adrenarche.

Rachel M Williams1, Caleb E Ward, Ieuan A Hughes

  • 1Department of Paediatrics, University of Cambridge, Cambridge, UK. rmw33@cam.ac.uk

Archives of Disease in Childhood
|August 13, 2011
PubMed
Summary
This summary is machine-generated.

Premature adrenarche, early development of secondary sexual hair, is common in children. While often benign, it requires excluding other conditions and may be linked to metabolic risks in some cases.

More Related Videos

Isolation of Preadipocytes from Broiler Chick Embryos
06:32

Isolation of Preadipocytes from Broiler Chick Embryos

Published on: August 4, 2022

Related Experiment Videos

Last Updated: May 30, 2026

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)
10:47

Rapid Detection of Neurodevelopmental Phenotypes in Human Neural Precursor Cells (NPCs)

Published on: March 2, 2018

Isolation of Preadipocytes from Broiler Chick Embryos
06:32

Isolation of Preadipocytes from Broiler Chick Embryos

Published on: August 4, 2022

Area of Science:

  • Pediatrics
  • Endocrinology

Background:

  • Premature adrenarche is defined as early development of secondary sexual hair in children, more common in girls.
  • It is a common pediatric presentation but necessitates exclusion of other androgen excess disorders.

Purpose of the Study:

  • To outline the diagnostic approach and management of premature adrenarche.
  • To discuss potential associations and long-term implications.

Main Methods:

  • Clinical history and examination are primary tools.
  • Initial investigations include serum androgen levels and bone age.
  • Further tests like synacthen stimulation test and adrenal ultrasound may be indicated.

Main Results:

  • Premature adrenarche is frequently benign but requires ruling out conditions like congenital adrenal hyperplasia or adrenal tumors.
  • Associated factors can include low birth weight and insulin resistance.
  • Potential links to adverse cardio-metabolic risk and polycystic ovarian syndrome exist in certain populations.

Conclusions:

  • Most cases of premature adrenarche require no specific treatment.
  • Metformin may be considered for children with low birth weight and insulin resistance on a case-by-case basis.