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Related Experiment Video

Updated: May 30, 2026

Ion-Exchange Membranes for the Fabrication of Reverse Electrodialysis Device

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Published on: July 20, 2021

The new advanced membrane gas exchanger.

Denis A Berdajs¹, Eleonora de Stefano, Dominique Delay

¹Department of Cardiovascular Surgery, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland. denis.berdajs@chuv.ch

Interactive Cardiovascular and Thoracic Surgery

|August 13, 2011

Summary

A novel, enlarged hollow-fiber oxygenator demonstrated superior oxygen transfer for cardiopulmonary bypass in large patients. This new device showed no increased blood trauma or clotting, suggesting its suitability for individuals with extensive body surface areas.

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Area of Science:

Cardiovascular Surgery
Biomedical Engineering
Medical Device Development

Background:

Standard membrane oxygenators are limited for patients with body surface area > 2.2 m².
Inadequate oxygenation can occur during cardiopulmonary bypass in patients with larger body surface areas.
Existing devices may not meet the physiological demands of patients with body surface area > 2.5 m².

Purpose of the Study:

To evaluate the efficacy of a novel hollow-fiber oxygenator with an enlarged surface area (1.81 m²) for cardiopulmonary bypass.
To compare gas transfer capabilities and blood trauma between the enlarged oxygenator and a standard device.
To assess the safety and performance of the enlarged oxygenator in large-body-surface-area subjects.

Main Methods:

An experimental study using six calves (mean weight 85.4 ± 3 kg) undergoing cardiopulmonary bypass.
Random assignment to either a standard oxygenator (1.35 m²) or the enlarged oxygenator (1.81 m²).
Blood sampling and analysis for oxygen transfer, plasma hemoglobin, lactate dehydrogenase, thrombocytes, and white blood cell counts over 6 hours of perfusion.

Main Results:

The enlarged oxygenator group exhibited significantly higher total oxygen transfer at 6 hours (P < 0.05).
No significant differences in blood trauma markers (plasma hemoglobin, lactate dehydrogenase) were observed between groups.
Thrombocyte and white blood cell counts, clot deposition, and peripheral emboli showed no significant adverse differences.

Conclusions:

The novel, enlarged hollow-fiber oxygenator provides superior gas transfer compared to standard devices.
The device demonstrates a favorable safety profile with no increased hemolysis or thrombotic events.
This enlarged oxygenator is a promising solution for adequate oxygenation in patients with large body surface areas during cardiopulmonary bypass.