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Proliferation and Differentiation of Murine Myeloid Precursor 32D/G-CSF-R Cells
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Recurrent spleen enlargement during cyclic granulocyte-macrophage colony-stimulating factor therapy for

A Delmer1, M Karmochkine, M Cadiou

  • 1Service d'Hématologie, Hôtel-Dieu, Paris, France.

American Journal of Hematology
|May 1, 1990
PubMed

A 65-year-old woman with refractory anemia with excess of blasts received sequential courses of granulocyte-macrophage colony-stimulating factor therapy (GM-CSF) and low-dose cytosine arabinoside. Each course of GM-CSF induced a rapid and tremendous increase in leukocyte count as well as in spleen size, 111indium chloride scanning suggested a myeloid metaplasia of the spleen. This observation suggests that in some patients the granulopoietic response to the myeloid growth factor stimulation may be predominant in the spleen.

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