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Related Concept Videos

Ischemic Stroke ll: Pathophysiology01:15

Ischemic Stroke ll: Pathophysiology

An ischemic stroke occurs when a cerebral blood vessel becomes obstructed, most often by a thrombus or embolus, interrupting the delivery of oxygen and glucose to brain tissue. Because neurons rely on continuous aerobic metabolism, energy failure begins within minutes of reduced perfusion. The region receiving the least blood flow becomes the infarct core, an area of irreversible cellular death. Surrounding this core lies the penumbra, a zone of hypoperfused but still viable tissue that is...
Ischemic Stroke l: Introduction01:15

Ischemic Stroke l: Introduction

Ischemic stroke is an acute cerebrovascular condition in which blood flow to a brain region is suddenly interrupted, leading to tissue infarction. Neurons depend on continuous oxygen and glucose supply, so even brief reductions in perfusion cause energy failure, ionic imbalance, and irreversible injury. Ischemic strokes are classified into thrombotic and embolic types based on their underlying mechanisms.Thrombotic MechanismsThrombotic stroke develops when a clot forms within a cerebral artery.

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Related Experiment Video

Updated: May 30, 2026

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia
10:13

Experimental Models to Study the Neuroprotection of Acidic Postconditioning Against Cerebral Ischemia

Published on: July 31, 2017

Remote ischemic per-conditioning: a novel therapy for acute stroke?

Cecil D Hahn1, Cedric Manlhiot, Michael R Schmidt

  • 1Division of Neurology, The Hospital for Sick Children and University of Toronto, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. cecil.hahn@sickkids.ca

Stroke
|August 13, 2011
PubMed
Summary

Remote per-conditioning, a technique involving transient limb ischemia, effectively reduces brain infarct size in a rat stroke model. This method shows promise for neuroprotection in acute ischemic stroke patients.

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Bilateral Common Carotid Artery Occlusion as an Adequate Preconditioning Stimulus to Induce Early Ischemic Tolerance to Focal Cerebral Ischemia
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Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents
07:52

Remote Limb Ischemic Preconditioning: A Neuroprotective Technique in Rodents

Published on: June 2, 2015

Area of Science:

  • Neuroscience
  • Cardiovascular Research
  • Ischemic Stroke Research

Background:

  • Remote ischemic conditioning protects organs from subsequent ischemia.
  • Per-conditioning, a form of remote ischemic conditioning during ischemia, offers cardioprotection.
  • This study investigates per-conditioning's neuroprotective potential in stroke.

Purpose of the Study:

  • To evaluate remote ischemic per-conditioning for neuroprotection.
  • To assess its efficacy in a clinically relevant rat model of acute ischemic stroke.

Main Methods:

  • A rat transient middle cerebral artery occlusion model was employed.
  • 39 rats were randomized to preconditioning, per-conditioning, or sham conditioning.
  • Infarct size was quantified 24 hours after 120 minutes of ischemia and reperfusion.

Main Results:

  • Both preconditioning and per-conditioning significantly reduced brain infarct size compared to controls.
  • Per-conditioning demonstrated superior neuroprotection compared to preconditioning.

Conclusions:

  • Remote per-conditioning via transient limb ischemia provides potent neuroprotection against regional brain ischemia-reperfusion injury.
  • Further research is needed to understand mechanisms before clinical trials for acute ischemic stroke.