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Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
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Identifying Per- and Polyfluorinated Chemical Species with a Combined Targeted and Non-Targeted-Screening High-Resolution Mass Spectrometry Workflow
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Delayed inflammation associated with retained perfluorocarbon liquid.

S Pradeep1, Jay K Chhablani, Bhavin Patel

  • 1Sankara Nethralaya, Chennai, Tamil Nadu, India.

Indian Journal of Ophthalmology
|August 13, 2011
PubMed
Summary
This summary is machine-generated.

Retained perfluorocarbon liquid (PFCL) after cataract surgery can cause delayed ocular inflammation. Prompt surgical intervention, such as vitrectomy, can restore good vision in affected patients.

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Area of Science:

  • Ophthalmology
  • Surgical Complications
  • Intraocular Surgery

Background:

  • Cataract surgery is a common procedure with a generally good safety profile.
  • Complications, though rare, can occur, necessitating further investigation and management.
  • Perfluorocarbon liquids (PFCLs) are sometimes used during complex intraocular surgeries.

Observation:

  • A 55-year-old woman developed ocular inflammation three months after cataract surgery.
  • Examination revealed frothy material, anterior chamber reaction, and a sulcus intraocular lens with a posterior capsule rent.
  • Fundoscopy and ultrasonography confirmed the presence of retained perfluorocarbon liquid (PFCL) in the vitreous cavity.

Findings:

  • Retained PFCL can lead to late-onset fibrinous inflammation, even after a period without symptoms.
  • The inflammation was characterized by anterior chamber reaction and the presence of PFCL bubbles and membranes in the vitreous.
  • Prompt diagnosis and surgical intervention are crucial for managing this complication.

Implications:

  • This case highlights the potential for retained PFCL to cause delayed inflammatory responses after intraocular surgery.
  • Surgical removal of retained PFCL, combined with anterior chamber washout, can result in favorable visual recovery.
  • Ophthalmologists should maintain a high index of suspicion for retained PFCL in patients presenting with late-onset ocular inflammation post-surgery.