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qPCR Is a Sensitive and Rapid Method for Detection of Cytomegaloviral DNA in Formalin-fixed, Paraffin-embedded Biopsy Tissue
Published on: July 9, 2014
Screening for cytomegalovirus during pregnancy
1Medical College of Virginia Campus, Virginia Commonwealth University, P.O. Box 980163, Richmond, VA 23298-0163, USA. Sadler@vcu.edu
Infectious Diseases in Obstetrics and Gynecology
|August 13, 2011
Summary
Cytomegalovirus (CMV) screening in pregnancy is becoming more feasible due to advances in understanding pathogenesis, identifying high-risk individuals, and improved diagnostic methods for both mothers and newborns.
Area of Science:
- Obstetrics and Gynecology
- Infectious Diseases
- Perinatal Medicine
Background:
- Cytomegalovirus (CMV) infections in pregnant women are a significant concern.
- Decades of research have focused on CMV epidemiology and pathogenesis.
Purpose of the Study:
- To highlight recent advancements making CMV serologic screening during pregnancy more attractive.
- To review developments in understanding CMV pathogenesis and diagnosis.
Main Methods:
- Review of recent developments in CMV research.
- Analysis of diagnostic methods for maternal and fetal CMV infection.
- Evaluation of indicators for neonatal outcomes.
Main Results:
- Understanding of CMV pathogenesis has advanced.
- Accurate serologic diagnostic methods for primary CMV infection are available.
- Methods for diagnosing fetal infection and predicting neonatal outcomes have improved.
- Potentially effective interventions are emerging.
Conclusions:
- Recent developments support the potential attractiveness of universal or limited serologic screening for CMV in pregnant women.
- Improved diagnostics and understanding of pathogenesis facilitate better management and outcomes.
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