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Updated: May 30, 2026

Synthesis of pH Dependent Pyrazole, Imidazole, and Isoindolone Dipyrrinone Fluorophores using a Claisen-Schmidt Condensation Approach
Published on: June 10, 2021
1-(3-Fluoro-phen-yl)-4,4,6-trimethyl-3,4-dihydro-pyrimidine-2(1H)-thione
Bohari M Yamin1, Ruhana L Lawi, Halima F Salem
1School of Chemical Sciences and Food Technology, Univeriti Kebangsaan Malaysia, UKM 43600 Bangi Selangor, Malaysia.
Abstract:
In the title compound, C(13)H(15)FN(2)S, the dihydro-pyrimidine ring is essentially planar, with a maximum deviation of 0.086 (3) Å from the mean plane of the rest of the ring for the dimethyl-ated C atom. The benzene ring is almost perpendicular to the dihydro-pyrimidine ring, with a dihedral angle of 83.97 (14)°. The crystal packing is characterized by centrosymmetric dimers resulting from pairs of inter-molecular N-H⋯S hydrogen bonds. There are also C-H⋯π inter-actions.
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