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Updated: May 30, 2026
Electrospun Nanofiber Scaffolds with Gradations in Fiber Organization
Published on: April 19, 2015
Bone regeneration with self-assembling peptide nanofiber scaffolds in tissue engineering for osseointegration of
Tomoyuki Kohgo1, Yoichi Yamada, Kenji Ito
1Department of Oral and Maxillofacial Surgery, Nagoya City University School of Medical Sciences, Nagoya, Japan.
Abstract:
The aim of this study was to evaluate the correlation between the osseointegration of dental implants and tissue-engineered bone using a nanofiber scaffold, PuraMatrix (PM). The first molar and all premolars in the mandibular regions of dogs were extracted, and three bone defects were prepared with a trephine bur on both sides of the mandible after 4 weeks. The experimental groups were as follows: (1) PM, (2) PM and dog mesenchymal stem cells (dMSCs), (3) PM, dMSCs, and platelet-rich plasma, and (4) control (defect only). Implants were placed in the prepared areas 8 weeks later and were assessed by histologic and histomorphometric analyses (bone-to-implant contact [BIC]). The BICs for groups 1, 2, 3, and 4 were 40.77%, 50.35%, 55.64%, and 30.57%, respectively. The findings indicate that PM may be useful as a scaffold for bone regeneration around dental implants.
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