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Colorectal carcinogenesis.

J E Payne1

  • 1Department of Surgery, University of Sydney, Repatriation General Hospital, Concord, New South Wales.

The Australian and New Zealand Journal of Surgery
|January 1, 1990
PubMed
Summary
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Genetic and environmental factors influence bowel cancer. Beer consumption and diet may increase left colon cancer risk, while Vitamin C might offer protection by inhibiting nitrosation.

Area of Science:

  • Gastroenterology
  • Oncology
  • Nutritional Science

Background:

  • Bowel cancer aetiology involves genetic and environmental factors.
  • Western diets high in protein, fat, and energy are linked to increased risk, particularly in the left colon.
  • Alcoholic beverage consumption, especially beer, is increasingly recognized as a potential risk factor for left colon and rectal cancers.

Purpose of the Study:

  • To review epidemiological data on bowel cancer.
  • To explore specific mechanisms of colorectal carcinogenesis.
  • To investigate the role of diet, N-nitroso compounds, and Vitamin C in bowel cancer development.

Main Methods:

  • Review of epidemiological studies on bowel cancer.
  • Discussion of animal carcinogens like dimethylhydrazine (DMH) and N-nitroso chemicals.

Related Experiment Videos

  • Analysis of recent findings on alkylating activity in food and Vitamin C's protective effects.

    • Main Results:

    • Environmental factors are more pronounced in the left colon.
    • Alcoholic beverages, particularly beer, are associated with left colon and rectal cancers.
    • Vitamin C may inhibit rectal cancer development, potentially by preventing nitrosation, and N-nitroso compound precursors are found in foods.

    Conclusions:

    • Further dietary studies are needed to understand N-nitroso carcinogenesis in relation to bowel cancer.
    • Complex interactions between inherited and environmental factors likely contribute to sporadic colorectal cancer.
    • Genetic changes, alongside environmental influences, play a role in colorectal cancer development.