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Updated: May 30, 2026

Photothrombosis-induced Focal Ischemia as a Model of Spinal Cord Injury in Mice
Published on: July 16, 2015
[The influence of photochromotherapy on the injured nerve under experimental conditions (a histological study)]
Abstract:
The objective of the present neurohistological study using an experimental model of compressive-ischemic neuropathy (40 white rats) was to estimate the influence of photochromotherapy on the injured nerve filament. It was shown that light of different wavelengths had differential effect on the nerve tissue. The exposure to blue light reduced the severity of traumatic lesion as apparent from a decrease in the number of filaments undergoing degenerative changes and their enhanced argentophilia. Irradiation with red light caused a marked decrease in the degree of vacuolization with moderate argentophilia suggesting normalization of ion transport and recovery of nerve conductivity. Green light irradiation promoted remyelinization of nerve filaments (a marked increase of the number of Schwann cells).

