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Updated: May 30, 2026

A 3D Human Lung Tissue Model for Functional Studies on Mycobacterium tuberculosis Infection
Published on: October 5, 2015
[Interleukin network in pulmonary tuberculosis]
Goro Matsuzaki1, Masayuki Umemura
1Molecular Microbiology Group, Department of Tropical Infectious Diseases, Tropical Biosphere Research Center, University of the Ryukyus.
Abstract:
Pulmonary tuberculosis is an infectious disease caused by Mycobacterium tuberculosis which establishes intracellular parasitism in phagosomes of macrophages as initial infection sites. When host immune system recognizes the bacteria, anti-mycobacterial immunity is activated by various cytokines including interleukins, tumor necrosis factor-alpha and interferon-gamma. The cytokines form a network of co-operative action and mutual regulation. In this review, role of the network of interleukins and cytokines in protection against pulmonary tuberculosis will be discussed.
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